Artigos Originais February 01, 2006 February 01, 2006

Contribution of post-breakfast plasma glucose to the glycemic control of type 2 diabetic patients

DOI: 10.1590/S0004-27302006000100008

Epidemiological studies have documented that postprandial hyperglycemia is the main risk factor for cardiovascular diseases. It has been established that glycated hemoglobin (HbA_1C) provides an integrated measure of plasma glucose (PG) of the last 2-3 months. However, the relative contribution of fasting PG (FPG) and postprandial PG (PPG) to the HbA_1C value is controversial. OBJECTIVE: To evaluate FPG and PPG contributions to the HbA_1C value in patients with type 2 diabetes mellitus (DM2). METHODS: 53 subjects with stable DM2 were studied. They were treated with oral anti-diabetic agents (n= 27) and/or insulin (n= 26). Each subject went to 3 visits at 2-month-intervals. On each visit, FPG, PPG (2h after breakfast and lunch), and HbA_1C were measured and we provided breakfast and lunch according to their meal habits. PG was measured by glucose-oxidase and HbA_1C by ion-exchange chromatography. Statistical analysis was performed by correlation coefficients at a <0.05 P value. RESULTS: Correlations were stronger between HbA_1C and post-breakfast PG (r: 0.66