Calorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie intake on aging is related to the reduction of body fat and insulin signaling as well as reactive oxygen species produced during breathing. These phenomena cause oxidative damage to DNA and RNA promoting […]

OBJECTIVE: To analyze the prevalence of obesity in elderly women and its association with socio-demographic, biochemical and hypertension variables. MATERIAL AND METHODS: By means of a cross sectional study, 188 outpatient women, 60 to 89 years-old were assessed. Obesity was defined by a BMI > 30Kg/m2 (WHO, 1998). The parameters examined were age, education, marital status, fasting glycemia, total cholesterol, high and low density cholesterol lipoproteins, triglycerides and presence or absence of blood hypertension. Data analysis was performed by Pearson’s […]

We evaluated 198 subjects between 50 and 85 years of age (older group) and 106 individuals of their offspring in the age group 11-49 years (younger group) in order to determine the frequency of thyroid dysfunction and also identify possible hormonal changes due to aging. The prevalence of thyroid dysfunction was similar in both groups (12.6% in the older and 14.1% in the younger groups). The positivity to one or two anti-thyroid antibodies was also similar between the groups (9.1% […]