Maternal diabetes constitutes an unfavorable environment for fetal-placental and embryonic development. It is has important repercussion in modern obstetrics, since it is associated to an increased risk of neonatal and maternal morbidity, and it still is a significant medical challenge. The increased occurrence of diabetes worldwide, the increase in diabetes type 2 in women at reproductive age and the crossed generation of intrauterine programming for diabetes type 2 are the bases for the growing interest in utilization of diabetic experimental […]

Much new information has been published in the last few years regarding pathophysiology of cardiovascular autonomic dysfunction in diabetic rats and mice. Our group has been studying the time-course cardiovascular changes associated with experimental diabetes in the last years, and obtained consistent evidences of severe dysautonomia in diabetes animal models. The aim of this manuscript is to review the contribution that studies involving different animal models of insulin deficiency or resistance have given to understand, treat and prevent diabetic cardiovascular […]

Obesity has been reported as a worldwide epidemic independent of economical and social conditions. The possible causes of increased mortality and morbidity associated with obesity have been focused by several studies that attempted to understand the syndrome X, one of the consequences of obesity. This syndrome is characterized by various metabolic disorders such as insulin resistance, hypertension and dyslipidemia. It is widely known that genetic factors influence the prevalence of obesity. However, the increasing rate of obesity over the past […]