ABSTRACT Objective Our aim was to describe the distribution of selected biomarkers according to age and sex, adjusted for HOMA-IR and adiposity, in a subset of middle-aged individuals of Brazilian Longitudinal Study of Adult Health-ELSA without diabetes mellitus or CVD. Subjects and methods This cross-sectional study was conducted in 998 participants of the ELSA-Brasil without diabetes and/or cardiovascular disease. In addition to the traditional risk factors, several biomarkers concentrations were compared according to sex, age groups (35-44; 45-54 yrs) and […]

The dyslipidemia of the metabolic syndrome (MS) confers an elevated cardiovascular risk and is characterized by increased concentrations of triglycerides, decreased HDL-cholesterol and qualitative alterations in LDL which renders it more atherogenic, like the small dense LDL. Modified forms of LDL (mLDL) have been detected in vivo in the plasma and atherosclerotic plaques. A minor fraction of the total LDL has an electronegative charge and is represented by a heterogenic subpopulation of particles [LDL(-)], with higher potential to induce endothelial […]

OBJECTIVE: to show a correlation between postprandial hypertriglyceridemia and cardiovascular risk factors to atherogenesis. RESEARCH DESIGN AND METHODS: 47 (30 women and 17 men, 40.5 ± 14.9years, body mass index: 26.1 ± 5.4kg/m2) non diabetic volunteers with normal (<200mg/dl) triglycerides were studied. Triglycerides, HDL-cholesterol and total cholesterol were measured before (basal), 3 and 5 hours after a 70g-lipid standardized test meal. RESULTS: patients with 3 hours postprandial hypertriglycerides higher than the 2nd Quartile (164.8mg/dl), in spite of normal fasting triglycerides, […]