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DOI: 10.1590/S0004-27302004000500019
Thomas Addison first described, 150 years ago, a clinical syndrome characterized by salt-wasting and skin hyperpigmentation, associated with a destruction of the adrenal gland. Even today, over a century after Addison’s report, primary adrenal insufficiency can present as a life-threatening condition, since it frequently goes unrecognized in its early stages. In the 1850’s, tuberculous adrenalitis was present in the majority of patients, but nowadays, autoimmune Addison’s disease is the most common cause of primary adrenal insufficiency. In the present report, […]
Keywords: Addison's disease; adrenal insufficiency; Anti-21-hydroxylase auto-antibodies; Anti-adrenal auto-antibodies; Autoimmune adrenalitis; Tuberculosis