Thyroid tumors originate from two cell types: 1) medullar carcinoma from parafolicullar cells and 2) the tumors derived from follicular epithelial cells, which include multinodular goiter, adenomas, differentiated carcinomas (papillary and follicular carcinoma) and undifferentiated carcinoma (anaplastic carcinoma). Because of the tumors distinct biological behavior, there is a requirement for a specific therapeutic approach. Some thyroid cancer specific mutations have been identified using molecular biology and more recently, genomic methodology. We now understand much of the alterations that occur in […]