Much new information has been published in the last few years regarding pathophysiology of cardiovascular autonomic dysfunction in diabetic rats and mice. Our group has been studying the time-course cardiovascular changes associated with experimental diabetes in the last years, and obtained consistent evidences of severe dysautonomia in diabetes animal models. The aim of this manuscript is to review the contribution that studies involving different animal models of insulin deficiency or resistance have given to understand, treat and prevent diabetic cardiovascular […]

Insulin therapy, regular physical activity and an individualized dietary plan are considered to be the ideal approach for the treatment plan of type 1 diabetes mellitus (T1DM) patients. Clinical and experimental studies have shown the benefits of exercise training in T1DM, as demonstrated by insulin sensitivity improvement, reduction in insulin requirement and an attenuation of autonomic and cardiovascular dysfunction. This review explores the physiological adaptations to exercise training in T1DM, and discuss the guidelines for physical activity recommendations and prescription […]