OBJECTIVE: To assess the effects of metformin (Met) on the endothelial dysfunction of the renal circulation of non-diabetic rabbits acutely induced by levels of glucose usually observed in diabetic patients in daily clinical practice. METHODS: Isolated perfused kidneys from non-diabetic rabbits were exposed for 3h to normal (100mg/dl – control group) or high (270mg/dl) D-glucose with or without Met (100µM). The glucose levels used correspond to 2h post-breakfast median values (272mg/dl) obtained from a cohort of 780 type 2 diabetic […]