Corticotropinomas represent approximately 80% of the etiology of Cushing’s syndrome in adults. In the past decade remarkable advances in the knowledge of the normal anterior pituitary development, in the pathogenesis of the pituitary tumors, as well as in the factors involved in the tumoral progression have been made. General principles of tumorigenesis are valid in corticotrophic tumors and it is clear that this is a multistep and multifactorial process, resulting from the interaction of initiating and promoting events. Most of […]