The activation of the leptin receptor recruits several intracellular signaling pathways, including the phosphatidylinositol 3-kinase (PI3K) pathway. While some of the leptin-induced signaling pathways, such as the JAK2/STAT3 pathway, induce cellular responses primarily through changes in gene expression, the PI3K pathway affects cellular properties more rapidly, through post-translational changes such as protein phosphorylation. Accordingly, several studies have shown that the PI3K pathway is required for the acute effects of leptin, such as a leptin-induced decrease in food intake. Leptin signaling […]

OBJECTIVE: To investigate the effect of nutritional recovery with rice bran on energy balance, leptin and insulin levels. METHODS: Weaned Wistar rats were fed on a 17% (Control – C) or 0.5% (Aproteic – A) protein diet for 12d. After this, rats were kept on a C diet (C) or recovered with control (Recovered Control – RC) or control plus recovered rice bran diet (Recovered Rice Bran – RRB). RESULTS: Despite the increased food intake, group A exhibited lower carcass […]

The aim of this study was to evaluate if obese women with the lowest values of caloric intake (CI) determined by food questionnaire also present the lowest values of resting metabolic rate (RMR), which could lead to excessive weight gain, caused by changes in energy balance. With this porpouse, 77 obese women, with IMC > 30kg/m2, aged 20 to 45 years, had their physical activity level and CI evaluated. According to the values of CI obtained from food intake reports, […]