OBJECTIVES: To evaluate the effects of an exercise program on handgrip strength (HS) in elderly women with low bone mass. SUBJECTS AND METHODS: Thirty-six elderly women were randomized to the intervention group – GI (n = 18) and control group – GC (n = 18). Participants were evaluated by means of a HS test, using a handgrip dynamometer. GI performed strength, balance and functional mobility exercises, and GC performed stretching exercises. Both groups had sessions twice a week for 50 […]

Metformin is one of the most commonly prescribed oral antidiabetic agents worldwide. However, its mechanism of action remains unknown. The Diabetes Prevention Program Research Group studies have shown that metformin administration and lifestyle-intervention (diet and exercise) reduce the incidence of Diabetes Mellitus type 2 (DM2). A possible biochemical connection between both therapies may be the AMP-activated protein kinase (AMPK). This enzyme was originally described as a sensor of cellular energy status, being activated in exercise. On the other hand, several […]