ABSTRACT Objective: To explore the impact of obesity on social phobia and the therapeutic effect of the antioxidant glutathione on this disorder. Methods: A total of 600 subjects were divided into an Obese Group and a Control Group. Four scales were utilized to determine social phobia, and magnetic resonance spectroscopy was applied to evaluate the central glutathione levels. Multivariate logistic regression was used for analysis. A mouse obesity model was subsequently established using a high-fat diet. Agonists or inhibitors were […]

ABSTRACT Objective Thyroid hormones are known to affect the biosynthesis and degradation of antioxidant compounds, suggesting a possible link between hypothyroidism and oxidative stress. However, there is no clear consensus in the literature regarding this association. The aim of this study was to evaluate oxidative stress markers (extracellular thiol-disulfide homeostasis and intracellular glutathione homeostasis) in patients with hypothyroidism due to autoimmune (Hashimoto’s thyroiditis) or nonautoimmune thyroid disease rendered euthyroid after levothyroxine replacement. Subjects and methods The study included 116 patients […]