This review summarizes the role of the molecular pathogenesis of Gsa protein gene in endocrine disease. G proteins transmit the cellular signal of 7 transmembrane receptors (7TM). Agonists as light photons, odorants and hormones (LH, FSH, TSH, PTH, etc) can activate the system. The effector of Gsa protein is adenyl-cyclase, which induces the formation of cAMP. The receptors that activate Gsa protein dissociates GDT into GTP, while the intrinsic GTPase activity hydrolyses GTP, keeping Gsa protein in its inactive state, […]