Abstract Objective: To assess whether plasma irisin is associated with anthropometric, body composition, and metabolic parameters according to body mass index. Methods: A prospective cohort study was conducted at a tertiary referral hospital in Southern Brazil. Patients were divided according to body mass index: Group 1 (body mass index = 18.5 – 29.9 kg/m2; n = 15), Group 2 (body mass index = 30 – 39.9 kg/m2; n = 36), and Group 3 (body mass index ≥ 40 kg/m2; n […]

ABSTRACT Objective: To evaluate the association between subclinical hypothyroidism and hepatic steatosis and fibrosis using the noninvasive diagnostic methods transient hepatic elastography (TE) and controlled attenuation parameter (CAP) in patients with subclinical hypothyroidism. Subjects and methods: This was a cross-sectional study including women with confirmed spontaneous subclinical hypothyroidism and an age- and body mass index (BMI)-matched control group without thyroid disease or circulating antithyroperoxidase (anti-TPO) antibodies. Exclusion criteria were age > 65 years, thyroid-stimulating hormone (TSH) > 10.0 mIUI/L, BMI […]

ABSTRACT Objective Provide a comprehensive view of the events surrounding the sugar consumption, under conditions of energy equivalence; through the analysis of behavioral aspects of intake, and of biochemical, metabolic and physiological parameters, as well as the effect of this nutrient on the plasticity of adipose tissue. Materials and methods Newly weaned male Wistar rats were classified in two groups and subjected to the following normocaloric diets: standard chow diet or to high-sugar diet (HSD) ad libitum for 18 weeks. […]