ABSTRACT Objective: Accurate assessment of metastatic status is crucial for determining radioactive iodine (RAI) dosing in postoperative papillary thyroid carcinoma (PTC) patients. This study aimed to identify unbiased biomarkers in metastatic PTC patients after surgery by applying a metabolomics workflow in saliva samples. Materials and methods: Saliva samples from 70 postoperative PTC patients (35 metastatic PTC patients in metastasis group and 35 non-metastatic PTC patients in control group) were analyzed using liquid chromatography – mass spectrometry. Orthogonal partial least-squares-discriminant analysis […]

Abstract Objective: To investigate the impact of laparoscopic sleeve gastrectomy (SG) on plasma metabolites in obese patients with type 2 diabetes mellitus (T2DM) and identify key metabolites associated with weight loss. Subjects and methods: Nineteen obese T2DM patients who underwent SG surgery were selected as the study participants. Preoperative and postoperative plasma samples and clinical data were collected. High-performance liquid chromatography-mass spectrometry (LC-MS/MS) was used to detect plasma metabolites, and changes in the levels of metabolites before and after surgery […]

ABSTRACT Metabolomics uses several analytical tools to identify the chemical diversity of metabolites present in organisms. These metabolites are low molecular weight molecules (