ABSTRACT Objective Incidental thyroid cancers (ITCs) are often microcarcinomas; among them, the most frequent histotype is the papillary one. The purpose of this study was to evaluate the rate of papillary thyroid cancer (PTC) in patients thyroidectomized for benign multinodular goiter. Subject and methods We retrospectively evaluated the histological incidence of PTC in 207 consecutive patients who, in a 1-year period, underwent thyroidectomy for benign multinodular goiter. All patients came from an iodine-deficient area (Orleans, France) with three nuclear power […]

Neoplastic transformation results from a series of genetic alterations involving activation of protooncogenes and inactivation of tumor suppressor genes. Activation of ras protooncogenes by point mutation is the most frequent genetic alteration in spontaneous thyroid neoplasias. The goal of this study was to evaluate ras gene expression in the nodular goiter. Seventy-nine patients submitted to thyroidectomy and with a histological diagnosis of nodular goiter were included in the study. Tissues were obtained from both tumor and normal thyroid during surgery […]

INTRODUCTION: Preservation of thyroid tissue in surgeries for multinodular goiter (MG) does not avoid hormonal replacement and may have nodular recurrence. Reoperations have a complication rate 20 times higher. We propose total thyroidectomy (TT) for MG as a definitive treatment. OBJECTIVE: To evaluate and justify the TT in patients with MG. MATERIAL AND METHOD: Retrospective study of 1,789 patients who underwent thyroidectomies, from 06/90 to 12/00. Indication, extension of thyroidectomy, cancer incidence and complications were analyzed. RESULTS: TT was performed […]