We present a case report that the patient had symptoms suggesting pheochromocytoma, a large tumor (> 50 g) and a single minimally altered laboratorial test, exemplifying a diagnostic pitfall. A 31y.o. male patient had two acute abdominal events, the last one accompanied by headache, arterial hypertension, facial flushing, perspiration and cutaneous pallor. In another admission, the patient had sustained arterial hypertension and cardiac arrhythmia. From laboratory analysis, the vanililmandelic acid was slightly modified. Scintigraphy disclosed a large adrenal mass suggesting […]

Arterial hypertension is associated with high morbidity and mortality indices and constitutes a major health problem worldwide, specially due to its high prevalence and low rate of control with the standard treatment. This problem can be explained, at least in part, because we still use empiric measures when choosing treatment options, instead of a rational approach for each case. The determinants of the hypertension remain unknown in the majority of patients and is designated as essential or primary hypertension. Hypertension […]

In this review we present practical aspects of thyroid molecular tumorigenesis. The most important issue is the molecular diagnosis of affected patients with RET mutations in families with medullary thyroid carcinoma and multiple endocrine neoplasia type 2. In addition, we discuss the molecular pathologenesis of differentiated thyroid carcinoma, like the data on RET/PTC rearrangements in papillary carcinoma and PAX8-PPARg1 rearrangement in follicular carcinoma. Subsequently, we present gain of function mutations in thyroid nodules and finally we conclude discussing the use […]