Hypoglycemia due to endogenous hyperinsulinism (EH) is diagnosed in a symptomatic patient with low levels of plasma glucose concomitant with elevated plasma insulin and C-peptide. Causes of EH are pancreatic islet-cells disease, use of insulin secretagogues, and autoimmune hypoglycemia. In this review, the authors studied 24 patients with hypoglycemia due to endogenous hyperinsulinism in order to describe aspects of diagnosis and treatment. Our study demonstrated that after 12 hours of fasting (mini-fasting test; at least three samples), all patients presented […]

Pancreas and kidney transplants have specific indications, benefits and risks. The procedure has become more common and more often as long-term success has improved and risks have decreased. Compared with a patient being on dialysis, simultaneous pancreas-kidney transplant offers a distinct advantage when it comes to mortality, quality of life and diabetic complications. Since there can be a living-donor kidney transplant,, a possibly similar patient and graft survival by 10 years follow-up, this procedure should be considered. Pancreas after kidney […]

The authors after presenting the magnitude of the problem of diabetes mellitus and diabetic nephropathy in Brazil and in the world made a review upon the point of view of the nephrologist about pancreas and pancreatic islet transplantation centered on the risks and benefits of the simultaneous pancreatic kidney transplantation (SPKT) for the diabetic with end-stage renal failure. In the paper it is stressed the importance of the interaction between the endocrinologist and the nephrologist for improving the survival of […]