ABSTRACT Objective: To evaluate the efficacy of radioactive iodine therapy and to identify determinants of treatment outcomes in young adults with Graves disease. Methods: This retrospective cohort study analyzed young adults with Graves disease who underwent radioactive iodine therapy at two tertiary medical centers in Southwest China. Patients were stratified into two groups based on therapy outcomes at 6 months post-radioactive iodine therapy: euthyroidism or hypothyroidism (therapy success) and persistent hyperthyroidism necessitating either a second radioactive iodine therapy or continuation […]

Graves’ disease is the most frequent cause of hyperthyroidism. Clinical thyrotoxicosis is directly caused by autoantibodies that activate the TSH receptor. The etiology is multifactorial, with genetic and nongenetic factors involveld. Current treatment options are antithyroid drugs (ATD), radioiodine (131I) and surgery. Radioactive iodine is increasingly being used as definitive therapy, because it long has proven to be a safe, nonexpensive and effective treatment. Recent publications have discussed the use of 131I associated with ATD as well as the identification […]