Hormone receptors and, specifically, estrogen receptors were described about four decades ago. For estrogens, there are two receptors, estrogen receptor alpha (ERa) and estrogen receptor b (ERb). The two receptors are coded by different genes and their tissue expression varies across organs. ERa is predominantly expressed in reproductive tissues (uterus, breast, ovaries) liver and central nervous system, whereas ERb is expressed in other tissues such as bone, endothelium, lungs, urogenital tract, ovaries, central nervous system and prostate. More than seventy […]