OBJECTIVE: To investigate the growth hormone (GH) response to glucagon stimulation test (GST) in a population of healthy men over 50 years old in comparison to insulin tolerance test (ITT), analysis of the spontaneous 24-hour GH profile and insulin-like growth factor 1 (IGF-I). METHODS: 27 healthy men aged between 51 and 65 years were tested. RESULTS: Using non-parametric correlation analysis, a positive correlation between GH peak after GST and mean IGF-I (r = 0.528; p = 0.005) was found, as […]

The extension of the life expectancy led to strategies aimed at improving the quality of life and productivity of aging persons. It is well known that, after the pubertal peak, the activity of the GH/IGF-1 axis progressively declines. Consequently, many normal individuals older than 60 years have 24-hour GH secretion indistinguishable from that of an adult patient with GH deficiency due to hypothalamic-pituitary lesions (ADGH). This physiological phenomenon is paralleled with many clinical aspects of ADGH, such as increased visceral […]