ABSTRACT Objective Incidental thyroid cancers (ITCs) are often microcarcinomas; among them, the most frequent histotype is the papillary one. The purpose of this study was to evaluate the rate of papillary thyroid cancer (PTC) in patients thyroidectomized for benign multinodular goiter. Subject and methods We retrospectively evaluated the histological incidence of PTC in 207 consecutive patients who, in a 1-year period, underwent thyroidectomy for benign multinodular goiter. All patients came from an iodine-deficient area (Orleans, France) with three nuclear power […]

INTRODUCTION: Preservation of thyroid tissue in surgeries for multinodular goiter (MG) does not avoid hormonal replacement and may have nodular recurrence. Reoperations have a complication rate 20 times higher. We propose total thyroidectomy (TT) for MG as a definitive treatment. OBJECTIVE: To evaluate and justify the TT in patients with MG. MATERIAL AND METHOD: Retrospective study of 1,789 patients who underwent thyroidectomies, from 06/90 to 12/00. Indication, extension of thyroidectomy, cancer incidence and complications were analyzed. RESULTS: TT was performed […]

A major issue influencing prescribing patterns of physicians has been the relative bioavailability and bioequivalence of commercial levothyroxine preparations. Some studies have suggested similar bioequivalence between various L-T4 tablets while other reports have found differences. Some of these studies have been criticized for methodological defects in patients’ selection or study design, which have become appreciated only in retrospect. Moreover the US Pharmacopeia has proposed that commercial tablets of L-T4 should be tested for its dissolution in two different solutions. Each […]