ABSTRACT Objective: The conversion of Hashimoto’s thyroiditis (HT) to hyperthyroidism due to thyrotropin receptor antibodies is intriguing and considered rare. The contribution of TSH receptor blocking antibodies (TRAb), which may be stimulators (TSAb) or blockers (TBAb), is suspected. We describe clinical and biological variables in a series of patients switching from Hashimoto’s thyroiditis to Grave’s disease. Subjects and methods: Retrospective case study of 24 patients with Hashimoto’s thyroiditis followed during 48 ± 36 months that developed later Graves’ disease (GD). […]

ABSTRACT Objective Thyrotoxicosis is established risk factor for osteoporosis due to increased bone turnover. Glucocorticoids often administered for Graves’ orbitopathy (GO) have additional negative effect on bone mineral density (BMD). Our aim was to examine the influence of thyroid hormones, TSH, TSH-receptor antibodies (TRAb) and glucocorticoid treatment on bone in women with Graves’ thyrotoxicosis and Graves’ orbitopathy (GO). Subjects and methods Forty seven women with Graves’ disease, mean age 55.6 ± 12.8 (23 women with thyrotoxicosis and 24 hyperthyroid with […]