To evaluate the prevalence of overweight and obesity in type 1 diabetes (DM1), we studied 170 subjects (89F/81M, 14 children, 51 adolescents and 105 adults, mean age 24.4±11.9y) and correlated anthropometric data with demographic and clinical factors. The prevalence of obesity, overweight and/or overweight risk was 21.2% (n= 36). Among children and adolescents BMI z score and BMI percentile were highly correlated (r= 0.97; p= 0.00). SBP (p= 0.004) and DBP (p= 0.0007) were different between patients with normal and […]

To evaluate the frequency of microalbuminuria and associated clinical and metabolic features, we studied 72 type 1 diabetic subjects [DM1, 38F/34M; 6 children, 17 adolescents and 49 adults; aged 22.7±9.5 years and with DM duration of 7 years (0.1-37.5)]. Urinary albumin excretion rate (AER) was determined in timed overnight urine samples by RIA. Microalbuminuria was defined when 2 out of 3 urine samples had AER in the range of 20-200mg/min. Microalbuminuria was present in 25% of our patients (16 adults […]

The main cause for mortality and the great morbidity in diabetes (DM) is atherosclerosis. A hypothesis for the initial lesion of atherosclerosis is endothelial dysfunction by recognizing that the endothelium plays a fundamental role in the maintenance of blood fluidity, vessel wall tone and permeability, the endothelium-derived nitric oxide (e-NO) being the main protector against atherosclerotic disease by inhibiting key pathways involved in atherogenesis. Endothelial dysfunction identified as an early marker of cardiovascular disease (CVD) could predict coronary artery disease […]

Diabetes mellitus and other categories of impaired glucose tolerance are frequent in the adult population and are associated with an increased risk for cardiovascular disease and microvascular complications. The diagnosis of these entities should be performed early and using sensitive and accurate methods, since lifestyle changes and correction of hyperglycemia may delay the incidence of diabetes and its complications. Glucose tolerance test is the reference method and the diagnosis of diabetes and impaired glucose tolerance are established when the 2h […]