When I was kindly asked by our editor-in-chief, Marcello Bronstein, to write an editorial about the article “Nutritional genomics, inflammation and obesity” ( ), the first title that came to my mind was “We are what we eat”. So, I logged in PubMed and set the title in to browse for articles with similar wording and, to my surprise, there were 98 hits. So, for the sake of originality, I picked another title, as you see in the top of […]

In this issue of Archives of Endocrinology and Metabolism , Pinto and cols. have performed a meta-analysis to investigate the association between type 2 diabetes (T2D) and the severity of COVID-19. The outcomes show that T2D seems to be a major, age-independent risk factor for the severity of this infection. The authors have included the first 7 published articles with a total of 1592 subjects, with data collected exclusively in the Chinese population, where the pandemic started (1). Simultaneously, other […]

There is a recent trend in the thyroid cancer literature towards a more conservative approach to papillary microcarcinomas of the thyroid gland. The widespread acceptance of lobectomy as adequate treatment for most patients is part of this tendency. Undoubtedly, the most conservative attitude concerning these indolent cancers is the active surveillance, pioneered by Miyauchi and Ito in Japan (-) and already being used in other centers around the world (,). In the present issue of Archives of Endocrinology and Metabolism […]

Active surveillance is defined as a strategy for treating a medical condition that involves a period of waiting and regular testing, rather than immediate treatment, such as surgery. In previous years, active surveillance (AS) of papillary thyroid microcarcinomas (mPTC; tumors with less than 1.0 cm) has been the focus of discussion worldwide, notably in the context of the epidemic of thyroid carcinomas diagnosed by neck imaging exams (). This practice was initially proposed in 1993 by Miyauchi and cols. and, […]

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PERSONAL BACKGROUND Amelita GALLI BELLISOMI (born in Milan, Italy, in the year of 1882 and died in 1963, in La Jolla, California, USA) was a prestigious coloratura soprano from the first half of the 20th century, well-known over the world. In her youth, she wished to become a piano soloist, but after an audition with a family friend, Pietro Mascagni (composer of Cavalleria Rusticana, L’amico Fritz, Le maschere, among others), he convinced her to pursue a career of opera singer. […]

Two studies published in this present issue of the Archives of Endocrinology and Metabolism, by Natalia Garcia Basavilbaso () and coworkers, as well as the one by Cesar Boguszewski and coworkers (), describe the treatment response in real-life of pegvisomant (PEGV) therapy in acromegaly patients, including aspects of safety and efficacy. Taken together, these data reflect the everyday practice results of 184 patients from 27 dedicated centers from Brazil and Argentina. These two essays are essential and very welcomed as […]

Dear readers, the Archives of Endocrinology and Metabolism is entering its fourth year of activities (), and this issue brings three important news which I would like to share with you: As Editor-in-Chief, I would like to acknowledge and thank the devoted and essential collaboration of our Associate Editors and Reviewers, as well as the Brazilian Endocrine Society (SBEM) Board of Directors for their constant support. Last but not least, I also want to extend my special thanks to the […]

Management of differentiated thyroid cancer (DTC) is highly dependent on risk stratification (,). An initial assessment of the risk of mortality and the risk of persistent/recurrent disease are required to guide treatment, follow-up and to set appropriate patients and physicians expectations with regard to the clinical outcomes after initial therapy. Therefore, much effort has been made for the improvement of long-term clinical risk predictors based on the information available at the time of diagnosis. In this issue of the Archives […]

Four years have elapsed since I took the post of Editor-in-Chief and changed the traditional “Arquivos Brasileiros de Endocrinologia e Metabologia” to “Archives of Endocrinology and Metabolism” (AE&M). This modification didn’t affect the pertinence of the journal to Brazil (it remained the official journal of the Brazilian Society of Endocrinology and Metabolism) but, using English as the official language, became more available to the scientific word. As a matter of fact, the submission of articles from abroad increased substantially, ranging […]

WHICH TEST SHOULD BE CHOSEN? Only a few institutions reported their experience and compared the performance of molecular tests in similar conditions. In one of them, two-thirds of Bethesda categories III and IV lesions were managed nonoperatively based on nonsuspicious results of Thyroseq® v2 or Afirma® GEC. Considering the rate of malignancy of 14%, Livhits and cols. () demonstrated that ThyroSeq® v.2 had a better performance to identify malignancy compared to GEC (PPV 57% vs. 39%). Similarly, Jug and cols. […]

Controlling loco-regional recurrence is an important goal for patients with differentiated thyroid cancer (DTC). A precise localization of suspected lesions is critical for patients with recurrence following a therapeutic neck dissection, as reoperations present increased morbidity. A focused excision may be justified, and marking of non-palpable lesions can help optimize surgical approach and increase tumor detection and removal. Radioguided occult lesion localization (ROLL) was initially described for breast tumors, and is based on the intra-operatory guidance by a hand-held gamma-probe […]