Arq Bras Endocrinol Metab 2009;53(4):429-434
Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced
DOI: 10.1590/S0004-27302009000400007
OBJECTIVE: To investigate the association between carbohydrate intakes and ?-cell function (HOMA-?) in Japanese-Brazilians with impaired glucose tolerance (IGT). METHODS: Dietary intakes were assessed by a validated food frequency questionnaire in a cross-sectional survey carried out in 2000. The associations between diet and HOMA-? were verified in 270 newly diagnosed IGT in multiple linear regression models. RESULTS: The mean (SD) age was 58 (11) years and the mean HOMA-? was 65 (47). The glycemic load was inversely associated with HOMA-?, ?1 -0.140 (95%CI = -1.044; -0.078), p = 0.023. The inverse association was also observed for refined grains intakes: -0.186 (95%CI = -0.4862; -0.058), p = 0.012. After adjustments for body mass index, the glycemic index was inversely associated with HOMA-?: -0.1246 (95%CI = -2.2482, -0.0257), p < 0.001. CONCLUSIONS: These data suggested that dietary glycemic load, glycemic index, and refined grains intakes are associated with reduced ?-cell function, and the quality of dietary carbohydrates may be relevant for maintaining ?-cell function among individuals with IGT.