Artigos Originais February 01, 2011 February 01, 2011

Effect of streptozotocin on the glycemic and lipid profiles and oxidative stress in hamsters

DOI: 10.1590/S0004-27302011000100006

OBJECTIVE: This study evaluated the effects of streptozotocin on glycemic and lipid profiles and oxidative stress status in hamsters. MATERIALS AND METHODS: Male Golden Syrian hamsters were divided in diabetic group (D) which received a streptozotocin single injection (STZ – 50 mg/kg), and control group (C) which received a single injection of the vehicle citrate buffer. Animals were euthanized after 10 days of experiment and blood, liver and kidneys were collected. RESULTS: The diabetic group had higher levels of glucose, triacylglycerols and cholesterol in serum and thiobarbituric acid reactive substances (TBARS) concentration increased in the liver and kidneys. Diabetes induced a significant increase in glutathione concentration in the liver and decreased paraoxonase and superoxide dismutase activities. CONCLUSION: Hamsters provide a novel animal model for diabetes mellitus and oxidative stress, similar to the human syndrome, which may be suitable for the testing of antidiabetic compounds.