Apresentação de Casos February 01, 2011 February 01, 2011

Growth hormone therapy and hypersensitivity type III reaction: a contraindication for desensitization

DOI: 10.1590/S0004-27302011000100011

Allergic reactions against GH are rare, and usually represented by the hypersensitivity type I (IgE-mediated). This type of reaction can be treated by desensitization. In this case report, we present a patient showing an allergic reaction soon after starting GH therapy mediated by immune complex (hypersensitivity type III reaction). In this condition, the attempt to perform the desensitization procedure can perpetuate immune complex deposition determining a life threatening renal and respiratory insufficiency.