original August 04, 2025 August 04, 2025

Pediatric Graves’ disease: insights into clinical characteristics and treatment outcomes

DOI: 10.20945/2359-4292-2025-0017

ABSTRACT

Objective:

To identify early manifestations of Graves’ disease in young patients and its treatment outcomes.

Subjects and methods:

This was a hospital-based review of case records of 47 children (aged 1 month to 18 years) with Graves’ disease from 2011 to 2022. Data were summarized and statistically analyzed.

Results:

This study included 47 patients with Graves’ disease, of whom 31 (66%) were girls. The average age at the initial diagnosis was 12.79 ± 3.75 years. Common presenting complaints included heat intolerance (76.6%), excessive sweating (74.5%), palpitations (68.1%), tremors (48.9%), weight loss (38.3%), increased appetite (34%), diarrhea (31.9%), and constipation (4.3%). The mean thyrotropin receptor antibody titer was 16.93 ± 13.47 IU/L. Remission was achieved in two (4.3%) patients treated with antithyroid drugs.

Conclusion:

Graves’ disease is the most common cause of juvenile hyperthyroidism, and treating physicians should be aware of its signs and symptoms to avoid treatment delays.