Arch. Endocrinol. Metab. 2018;62(4):383-385
Region-specific reference intervals for TSH in pregnancy: time for changes in Brazil
DOI: 10.20945/2359-3997000000067
Over the past few years, the diagnosis of thyroid disorders during pregnancy has emerged as one of the major focuses of debate in clinical thyroidology. Whether we should or not universally screening all pregnant women in the first trimester of pregnancy () and what is the best pregnancy-trimester specific TSH reference range (-) has gained worldwide interest. Answers are necessary to guide clinicians and public health policies.
It is well-known that many complex physiological adaptations in the thyroid economy occur over a normal pregnancy (). In summary, the increased concentration of hepatic thyroid-binding globulin, of human chorionic gonadotropin, and the elevation of iodide renal clearance, stimulate the maternal thyroid machinery. All together, they lead to marked differences in TSH and thyroid hormone concentrations among pregnant and non-pregnant women, making interpretation of thyroid function tests difficult ().
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