Letter to the editor October 08, 2025 October 08, 2025

Response to the letter to the editor: Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study

DOI: 10.20945/2359-4292-2025-0356

Dear Editor,

We thank Dr. Rahim and Dr. Khurshid for their thoughtful comments regarding our study entitled “Stress-induced hyperglycemia and expression of glucose cell transport genes in skeletal muscle of critically ill patients: a cross-sectional study”(). Their insights enrich the ongoing discussion about the metabolic alterations that occur during critical illness. The authors point out several factors that could confound the interpretation of insulin receptor substrate 1 (IRS1) downregulation in the context of stress-induced hyperglycemia. We would like to take this opportunity to address their concerns.

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