Archives of Endocrinology and Metabolism
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Instructions for authors

We emphasize the importance of following these instructions carefully. Failure to do so will delay the processing of your manuscript.
Manuscripts should be submitted solely to the AE&M and should not have been published, or be under consideration for publication in any substantial form, in another periodical-either professional or lay.
Manuscripts should be submitted in English. Proofreading by a scientific editing service is strongly recommended; the following companies are suggested: Voxmed Medical Communications, American Journal Experts and PaperCheck. Manuscriptss that successfully complete the peer-review process and are recommended for publication will only be accepted and published upon receipt of a certificate proving
professional academic English proofreading. In extraordinary circumstances, the certificate can be waived by editorial decision.
Papers that do not meet these requirements will be returned to the author for the necessary revisions before formal review.
Authors must include the ORCID (Open Researcher and Contributor ID) in the article submission and in the manuscript file.
All submissions are initially evaluated in depth by the scientific editors. Papers that do not conform with the general criteria for publication will be returned to the authors without detailed review, typically within three to five days. Otherwise, manuscripts will be sent to reviewers (most commonly two).

Reports of original research may be submitted to AE&M as Original Articles or Brief Reports. Other special categories of manuscripts are described below. All manuscripts must adhere to the word count limitations, as specified below, for text only; word count does not include the abstract, references, or figures/tables and their legends. Word count must be shown on the title page, along with the number of figures and tables. The format is similar for all manuscript categories, and it is described in detail in the “Manuscript Preparation” section.

Original Articles
The Original Article is a scientific report of the results of original research that has not been published or submitted for publication elsewhere (either in print or electronically). It represents a substantial body of laboratory or clinical work. In general, Original Articles should not exceed 3,600 words in the main text, include more than six figures and tables, or more than 35 references.

Review Articles
The AE&M publishes Review Articles that show a balanced perspective on timely issues within the field of clinical endocrinology. All reviews are submitted upon invitation and are subject to peer review. Articles in this category are requested by the Editors to authors with proven expertise in the field. Authors considering the submission of uninvited reviews should contact the editors in advance to determine whether the topic that they propose is of current potential interest to the Journal. Review articles should be no longer than 4,000 words in the main text, include no more than four figures and tables, and no more than 60 references. The author should mention the source and/or request authorization for use of previously published figures or tables.

Consensus Statements
Consensus Statements related to the endocrine and metabolic health standards and healthcare practices may be submitted by professional societies, task forces, and other consortia. All such submissions will be subjected to peer review, must be modifiable in response to criticism, and will be published only if they meet the usual editorial standards of the Journal. Consensus Statements should typically be no longer than 3,600 words in the main text, include no more than six figures and tables, and no more than 60 references.

Brief Report
The Brief Report consists of new data of sufficient importance to warrant immediate publication. It is a succinct description of focused study with important, but very straightforward, negative or confirmatory results. Brevity and clarity are always likely to enhance the chance of a manuscript being accepted for publication. A maximum of 1,500 words in the main text plus up to 20 references and normally no more than two illustrations (tables or figures or one of each) are acceptable for Brief Reports.

Case Report
A Case Report is a brief communication presenting collected or single case reports of clinical or scientific significance. These reports should be concise and focused on the issue to be discussed. They should address observations of patients or families that add substantially to the knowledge of the etiology, pathogenesis, and delineation of the natural history or management of the condition described. Case Reports should be 2,000 words or less, with no more than four figures and tables, and no more than 30 references. 

We emphasize that only case reports that offer important basic translational or clinical contributions, preferentially together with a review of the literature, will be considered for publication.

Letters to the Editor
Letters to the Editor may be submitted in response to manuscript that has been published in the Journal. Letters should be short commentaries related to specific points of agreement or disagreement with the published manuscript. Letters are not intended for the presentation of original data unrelated to a published article. Letters should be no longer than 500 words, with no more than five complete references,
and should not include any figures or tables.


The Journal requires that all manuscripts be submitted in a single-column format that follows these guidelines:
• The manuscript must be submitted in MS-Word format.
• All text should be double-spaced with 2 cm margins on both sides using 11-point type Times Roman or Arial font.
• All lines should be numbered throughout the entire manuscript and the entire document should be paginated.
• All tables and figures must be placed after the text and must be labeled. Submitted papers must be complete, including the title page, abstract, figures, and tables.
Papers submitted without all of these components will be placed on hold until the manuscript is complete.

• A cover letter requesting the evaluation of the manuscript for publication in AE&M, and any information relevant to the manuscript. The manuscript´s originality and exclusivity should be stated, as well as the contribution of each author, Elsewhere on the submission form, authors may suggest up to three specific reviewers and/or request the exclusion of up to three others. The manuscript must be presented in the following order:
1. Title page.
2. Structured abstract (or summary for case reports).
3. Main text.
4. Tables and figures. They must be cited in the main text in numerical order.
5. Acknowledgments.
6. Funding statement, competing interests and any grants or fellowships supporting the writing of the paper.
7. List of references.

Title Page
The title page must contain the following information:
1. Title of the article (a concise statement of the major contents of the article).
2. Full names, departments, institutions, city, and country of all co-authors.
3. Full name, postal address, e-mail, telephone and fax numbers of the corresponding author.
4. Abbreviated title of no more than 40 characters for page headings.
5. Up to five keywords or phrases suitable for use in an index (the use of MeSH terms is recommended).
6. Word count – excluding title page, abstract, references, figures/tables and their legends.
7. Article type

Structured Abstracts
All Original Articles, Brief Reports, Reviews, Case Reports should be submitted with structured abstracts of no more than 250 words. The abstract must be self-contained and clear without reference to the text, and should be written for general journal readership. The abstract format should include four sections that reflect the section headings in the main text. All information reported in the abstract must appear in
the manuscript. Please use complete sentences for all sections of the abstract.

The article should begin with a brief introductory statement that places the study in historical perspective, and explains its objective and significance.

Materials and Methods

These should be described and referenced in sufficient detail for other investigators to be able to repeat the study. The source of hormones, unusual chemicals and reagents, and special pieces of apparatus should be stated. For modified methods, only the modifications need be described.

Results and Discussion

The Results section should briefly present the experimental data in text, tables, and/or figures. For details on preparation of tables and figures, see below. The Discussion should focus on the interpretation and significance of the findings, with concise objective comments that describe their relation to other studies in that area. The Discussion should not reiterate the Results.


The AE&M ascribes to the authorship and contributorship guidelines defined by the International Committee of Medical Journal Editors ( Unrestricted joint authorship is allowed. A maximum of two corresponding authors is allowed. The uniform requirements for manuscripts submitted to medical journals state that authorship credit should be based only on substantial contribution to:
1. The conception and design, or analysis and interpretation of data.
2. The drafting of the article or its critical review for important intellectual content.
3. The final approval of the version to be published.
All these conditions must be met. The corresponding author is responsible for ensuring that all appropriate contributors are listed as authors, and that all authors have agreed with the content of the manuscript and its submission to the AE&M.

Conflict of interest
A conflict of interest statement for all authors must be included in the main document, following the text, in the Acknowledgments section. If authors have no relevant conflict of interest to disclose, this should be indicated in the Acknowledgments section. 

The Acknowledgments section should include the names of those people who contributed to a study but did not meet the requirements for authorship. The corresponding author is responsible for informing each person listed in the acknowledgment section that they have been included and providing them with a description of their contribution so they know the activity for which they are considered responsible. Each person listed in the acknowledgments must give permission – in writing, if possible – for the use of his or her name. It is the responsibility of the corresponding author to provide this information.

References to the literature should be cited in numerical order (in parentheses) in the text and listed in the same numerical order at the end of the manuscript on a separate page or pages. The author is responsible for the accuracy of references. The number of references cited is limited for each category of submission, as indicated above.

Tables should be submitted in the same format as the article (Word), and not in another format. Please note: we cannot accept tables as Excel files within the manuscript. Tables should be self-explanatory and the data they contain must not be duplicated in the text or figures. Tables must be constructed as simply as possible and be intelligible without reference to the text. Each table must have a concise heading. A description of experimental conditions may appear together with footnotes at the foot of the table. Tables must not simply duplicate the text or figures.

Figures and Legends
All figures must display the figure number. Sizing the figure: the author is responsible for providing digital art that has been properly sized, cropped, and has adequate space between images. All color figures will be reproduced in full color in the online edition of the journal at no cost to the authors. Authors are requested to pay the cost of reproducing color figures in print (the publisher will provide price quotes upon acceptance of the manuscript).

The AE&M strongly prefers to publish unmasked patient photos. We encourage all prospective authors to work with families prior to submission and address the issue of permission for review and possible  publication of patient images. If your submission contains ANY identifiable patient images or other protected health information, you MUST provide documented permission from the patient (or the patient’s parent, guardian, or legal representative) before the specific material circulates among editors, reviewers and staff for the purpose of possible publication in AE&M. If it is necessary to identify an individual, use a numerical designation (e.g. Patient 1) rather than using any other identifying notations, such as initials.

Units of Measure

Results should be expressed in metric units. Temperature should be expressed in degrees Celsius and time of day using the 24-hour clock (e.g., 0800 h, 1500 h).

Standard Abbreviations
All abbreviations must be immediately defined after it is first used in the text.

Experimental Subjects
To be considered for publication, all clinical investigations described in submitted manuscripts must have been conducted in accordance with the guidelines of The Declaration of Helsinki, and must have been formally approved by the appropriate institutional review committees or their equivalent.
The study populations should be described in detail.
Subjects must be identified only by number or letter, not by initials or names. Photographs of patients’ faces should be included only if scientifically relevant. The authors must obtain written consent from the patient for the use of such photographs. For further details, see the Ethical Guidelines.
Investigators must disclose potential conflict of interest to study participants and should indicate in the manuscript that they have done so.

Experimental Animals 

A statement confirming that all animal experimentation described in the manuscript was conducted in accordance with accepted standards of humane animal care, as outlined in the Ethical Guidelines, should be included in the manuscript.

Ethical Guidelines
All studies involving human research must be in accordance with the Declaration of Helsinki and must have been formally approved by the appropriate institutional review board, ethical review committee, or equivalent. Concerning research conducted in Brazil, all studies must inform the CAAE (Certificado de Apresentação para Apreciação Ética) registration number generated in Plataforma Brasil.
In all experiments involving human subjects, it should be stated that informed consent was obtained from the participants and that an institutional human research committee had approved the investigations. This should be stated in the Methods section of the manuscript.
Regarding studies involving experimental animals, a statement confirming that all experimentation was performed according to accepted standards of humane animal care should be included in the manuscript.

Molecular Genetic Description
• Use standard terminology for variants, providing rs numbers for all variants reported. These can be easily derived for novel variants uncovered by the study. Where rs numbers are provided, the details of the assay (primer sequences, PCR conditions, etc.) should be described very concisely.
• Pedigrees should be drawn according to published standards (See Bennett et al. J Genet Counsel (2008) 17:424-433 - DOI 10.1007/s10897-008-9169-9).

• For genes, use genetic notation and symbols approved by the HUGO Gene Nomenclature Committee (HGNC) – (
• For mutation nomenclature, please use the nomenclature guidelines suggested by the Human Genome Variation Society (
• Provide information and a discussion of departures from Hardy-Weinberg equilibrium (HWE). The calculation of HWE may help uncover genotyping errors and impact on downstream analytical methods that assume HWE.
• Provide raw genotype frequencies in addition to allele frequencies. It is also desirable to provide haplotype frequencies.
• Whenever possible, drugs should be given their approved generic name. Where a proprietary (brand) name is used, it should begin with a capital letter.
• Acronyms should be used sparingly and fully explained when first used.

Papers must be written in clear, concise English.
Avoid jargon and neologisms. The journal is not prepared to undertake major correction of language, which is the responsibility of the author. Where English is not the first language of the authors, the paper must be checked by a native English speaker.
For non-native English speakers and international authors who would like assistance with their writing before submission, we suggest Voxmed Medical Communications, American Journal Experts or PaperCheck.
ISSN 2359-3997 © A&EM – Rua Botucatu, 572 – conjunto 83 – 04023-062 – São Paulo, SP, Brazil

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